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Title: Lymphoma-associated myeloid-monocytic (LAMM) cells mediate resistance against CAR-T cell therapy in aggressive B-cell lymphoma
CAR-T cell therapy has improved the outcome of patients with relapsed or refractory (r/r) aggressive B cell lymphoma. However, around 60% of patients do not derive durable benefit from CAR-T cell therapy. To elucidate hallmarks associated with an immunosuppressive lymphoma microenvironment and CAR-T cell resistance, we applied high-dimensional analyses to pre- and post-CAR-T cell specimens. In patients with non-durable response, we identified a prognostically relevant lymphoma-associated myelo-monocytic (LAMM) gene signature.
Speaker: Prof. Dr. Dr. Roland Ullrich
Department I of Internal Medicine, University Hospital Cologne
About the speaker: Roland Ullrich studied medicine in Marburg, Cologne, Paris and Lyon. After his study he worked as a Post-Doc at the Max-Planck-Institute for neurological research and started his own independent research group at the Max-Planck Institute for neurological research in 2009. Since 2015 he is heading a Research group at the TRIO in Cologne. His group applies chemical genetics and in vivo approaches to investigate the role of the lymphoma microenvironment (LME) in impairing BsAb- or CAR T cell-mediated anti-lymphoma immunity, as well as the underlying molecular mechanisms contributing to therapy resistance and failure. Herein, we aim to unravel the immunosuppressive capacity of the LME, with a particular focus on myeloid-monocytic cells, which present a promising therapeutic target in combination with CAR T cells and BsAbs. Our ultimate goal is to identify novel strategies that enhance therapy responses in r/r B cell lymphoma patients.
Organizer: Angeliki Stamtsis-Datsi
Contact: youngimmunologists@dgfi.org
Together with the YI podcast host Nóra Balzer, YI proudly presents the start of the second podcast season! New content on academic research topics and beyond will be published every month.
In this special holiday edition, the Young Immunologist Board of the German Association of Immunology has shared their top advice to help YOU level up your scientific career in 2025. Whether you’re just starting out in your PhD or gearing up for your next big career move, this episode is packed with tips you don’t want to missent of the biotech field. The gender gap in science startups and the mindset change in science towards entrepreneurship are debated as well.
Tune in: all ImmunoChat episodeWe also encourage you to revisit some of our current episodes. Whether you’re catching up on missed episodes or re-listening to your favorites, there’s plenty of content to keep you engaged and informed.
Curious? Follow the link and let us know your thoughts via our socials or e-mail to youngimmunologists@dgfi.org.
Read about the podcast in EJI (https://onlinelibrary.wiley.com/doi/10.1002/eji.202350595).
Programming skills are becoming more important. Our YI* Coding Club conducts in-person meetups with advanced researchers, an online seminar including a hands-on tutorial by one of our YI members and an online summer programming session on R introduction focused on data visualization. Find us on a slack channel in the YI community slack workspace.
In this series of lectures, the DGfI Commission on Gender Equality and Career Development provides a forum for excellent female immunologists. They will share their exciting research, but also talk about their experiences in forming a career as women in STEM (=MINT).
Programme
21.05.2025 | 4-6pm | Prof. Dr. Eva Tolosa
Further activities:
- Regular local round-table meetings: For example, in Hamburg and Freiburg these meetings were organised in person and we encourage you to implement this in your city as well - maybe also in an online format! Find out who works in your area and get involved with YI members across Germany and Europe through our „YI Community“ in Slack!
- We are especially keen on engaging in public outreach work, please approach us if you would have time or ideas for implementing this! Please contact the yEFIS Communication Working Group.
- Any other ideas? Approach us with new input. You can reach us via youngimmunologists@dgfi.org.
YI contributions for the Annual DGfI meetings
- Young Immunologists Symposium: YI members can present their work on the big stage to gain valuable presentation experience and chances to win attractive prizes!
- YI Social Evening to foster networking and exchange
- To support researchers with young children we organize on-site childcare.
- YI lunch session which includes the YI General Assembly followed by an open discussion round
- YI booth at the industry exhibition
yEFIS:
The EFIS Young Immunologist Task Force (yEFIS) aims to gather all early career scientists in Europe working in Immunology. Within the different European Immunology Societies, self-organised Young Immunologist (YI) groups have arisen in the last years. However, there has been limited contact between them. The aim of yEFIS Task Force is to bring all these YI groups together and build a European network to defend our interests on both a national and European level. EFIS provided us the ideal platform to start up this network and this is how in 2020 yEFIS Task Force and yEFIS Network were born.
On July 30, yEFIS had their kick-off meeting. 70 interested young immunologists from the whole of Europe tuned in. With Santiago Costas (our official representative of the DGfI YI at yEFIS), Ellen McAllister and Anne Hahn, three of our DGfI YI board members have been deeply involved in the set-up.
yEFIS already has 270 members from 20 different European countries! You can see how widely yEFIS covers Europe already. Check out the EFIS website for further information incl. registration.